Living With Mesothelioma -My Diary- Kent County Show, Rain, Earthquakes, and the Command Trial


We are having such bad weather but only here in East Kent by the looks of the lovely sunshine everywhere else. Then On the news the reason came to light.

The Kent County Show Is on. It always rains  when the show is  on.Ok last year was lovely but that was so rare

http://www.kentonline.co.uk/maidstone/news/kent-county-show-opens-its-19871/

 

The Kent County Show is a showcase event for farming, countryside and rural life.  The three day event brings together the very best of Kent with animals and food, fun and excitement and above all a sense of what ‘The Garden of England’ has to offer.

The Kent County Show 2014 will be on Friday 11, Saturday 12 and Sunday 13 July has something for the whole family.  Open from 8am to 6pm every day, the Show is a wonderful day out with plenty of displays, entertainment and local food.  With over 400 exhibitors and trade stands and over 300 competitions, activities and displays.

The Agricultural area of the Show boasts large displays of cattle, sheep and goats as well as a large Poultry and Egg show. Livestock competitions, sheep shearing demonstrations and modern machinery displays take place throughout the day. A visit to the Wool Tent will educate visitors on the different types of wool, allowing them to feel each of the fleeces on display. The impressive display from Kent Young Farmers Clubs can also be found in this area, showcasing all the animals from their farms. These dedicated students take part in animal judging classes and fun classes such as fancy dress and It’s a Knockout.

I have to admit that as it is only down the M2 from here I have never been. Mainly I have always been away at a Rally somewhere but since my illness the thought of strolling around in all the mud does put me off a bit.

The queue to get into the show is another no no!!

So We will stay home in the dry and I will turn out my wardrobes. I want to garden but its so wet. No wonder they say “make hay while the sun is shinning”

We had a slow day yesterday because of the weather and I repolished and re wiped everywhere. We really should go away and enjoy a few days. I do hope the weather is Ok in August as we have a lot planned.

I do work in the den though answering emails and working on Face book.

The storyline on Emmerdale is hotting  up and Donna is getting worse. On the F/B site though the question is coming up time and time again that Donna is to well. I have intervened and explained how people keep saying to me how well I look. I always answer -Its what is going on inside. It truly is one of the several illness’s that because people cant see it then it isn’t happening.

You shouldnt have to keep justifying why that is as it just is. We should always have sympathy for those people. The times someone has got out of the car when parked in a disabled bay and people have looked perplexed because they seem so mobile. They have to put a blue badge up before people believe they are parked in the right area. I do feel guilty but I do need to be near to the door of a supermarket as pushing the trolley around these vast stores and loading onto the conveyor belt, then pack my bags and walk to the car, is so tiring and Im exhausted.

Im proud of the walks I do do. Like yesterday we went to Tankerton and walked to the dogs shop to treat Louis to chews and Chocolates.

It wasn’t raining so it was great to be out in the fresh air.

We seem to be getting more and more earthquakes –

A noteworthy 4.5M (some agencies 4.0M) earthquake occurred near the shores of France in the English Channel.

Surely this was felt by residents along both coasts of England, and France.  Possibly also felt in Belgium, Spain, Netherlands, Germany, and Luxembourg.

A noteworthy 4.5M (some agencies 4.0M) earthquake occurred near the shores of France in the English Channel.

Surely this was felt by residents along both coasts of England, and France.  Possibly also felt in Belgium, Spain, Netherlands, Germany, and Luxembourg.

3.9-m-earthquake-north-sea-july-11-2014a-4.5

 

 

 

 

 

http://dutchsinse.tatoott1009.com/7112014-4-5m-earthquake-strikes-the-english-channel-france/

BBC Radio Jersey presenter Sara Palmer had just loaded up the Status Quo song when quake struck at a depth of seven miles (12km) around 12 miles (20km) west of St Helier at 12.54pm.

The DJ said afterwards: “I could see the monitors in front of me shake. It was really odd, we all looked wide-eyed at each other.”

There were no reported injuries but the tremor shook homes, frightened residents and registered on monitoring equipment as far away as Exeter, Devon – some 150 miles away.

It was the largest to hit the Channel Islands since a 5.6 magnitude quake struck right to the east of Guernsey in 1926 but its effects were much more violent.

http://www.telegraph.co.uk/earth/earthnews/10963031/Jersey-Earthquake-disturbs-Status-Quo.html

I dont think we should have Fracking as this will make us unstable even more.

Verastem

On the Mesothelioma side Bernie Banton Rod announced after talking to Verastem—-12/07/2014 – Australia
The Verastem COMMAND phase two mesothelioma trial for sufferers of pleural mesothelioma is now open and recruiting sufferers in Sydney and Perth, Australia and Auckland, New Zealand.
It will also be opening and recruiting sufferers at the Peninsula Oncology Centre, Frankston (Melbourne) with in weeks.
This trial is a ‘placebo trial’ that is open to sufferers who have only had cisplatin and/or carboplatin with pemetrexed (Alimta) as chemotherapy treatment.
To find out if you, or someone you know may be interested, is eligible and exactly where the the trials are being conducted, click on the link below, or contact me by messaging me on Facebook:
www.facebook.com/RodSmith.MrAntiAsbestos
or emailing me: angels@berniebanton.co.au

Im so pleased they will have this trial available as it is doing very well. Although 2 friends that have been on it have had it cancelled but maybe they were on the placebo. I hate that as it does waste our valuable time that we havent a lot of.

Verastem, Inc. (NASDAQ: VSTM) is a clinical-stage biopharmaceutical company focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells. Cancer stem cells are an underlying cause of tumor recurrence and metastasis. Verastem is developing small molecule inhibitors of signaling pathways that are critical to cancer stem cell survival and proliferation: FAK, PI3K/mTOR and Wnt.

They are a very dedicated Company and they held their annual Research and Development Day

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Jul. 10, 2014– Verastem, Inc. (NASDAQ:VSTM), focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, today hosted its annual Research and Development Day at the Hudson Theatre in the Millennium Broadway Hotel in New York City.

“We continue to see promising clinical signals from the VS-6063 program,” said Dr. Joanna Horobin, Verastem Chief Medical Officer. “An additional partial response has been reported since our interim report at ASCO on the combination of VS-6063 and weekly paclitaxel in twenty-two patients with ovarian cancer. To date, best clinical response of at least stable disease has been observed in 14 of the 22 patients (64%). This comprises two complete responses, three partial responses and nine patients with stable disease, including four patients whose disease has been stable for 6 months or longer. Eight patients continue on study drug. Based on this encouraging activity, we are planning a controlled Phase 2 study in patients with platinum resistant ovarian cancer.”

Members of the Verastem leadership team provided in-depth reviews of the Company’s development programs targeting cancer stem cells with a focus on lead inhibitor VS-6063. VS-6063 targets cancer stem cells through the inhibition of focal adhesion kinase (FAK). The review of Verastem’s clinical programs included a presentation of clinical and preclinical data obtained to date, updated development plans, guidance for key upcoming milestones and commentary by guest speakers.

“It is well known that in patients undergoing cancer treatment, tumors often become resistant to standard therapies resulting in disease progression. We believe that cancer stem cells are an underlying cause of this failure,” saidRobert Forrester, Verastem President and Chief Executive Officer. “By targeting cancer stem cells, we want to change the way that cancer is treated. We have made significant progress in the past 12 months and have continued to further scientific understanding with all of our product candidates. Encouraged by these initial signs of clinical activity, we are adding additional studies to further test our hypothesis that the targeting of cancer stem cells may enable a more durable clinical response.” http://phx.corporate-ir.net/phoenix.zhtml?c=250749&p=irol-newsArticle&ID=1946624&highlight=

About COMMAND

COMMAND is a registration-directed, double-blind, placebo-controlled trial of VS-6063 with PFS and OS as the primary endpoints. VS-6063 targets cancer stem cells. Cancer stem cells are an underlying cause of tumor progression and recurrence. The design of COMMAND allows the opportunity to enrich for patients with tumors low in the biomarker, merlin. Preclinical and early clinical research has demonstrated that low merlin levels may be predictive of increased effectiveness of FAK inhibitors such as VS-6063. The COMMAND study stratifies patients to evaluate the effect of VS-6063 in both the overall patient population and the subgroup of patients whose tumors are low in merlin.

COMMAND is expected to enroll approximately 350-400 patients at clinical sites in 12 countries, including the US,UK, Japan, Australia, Canada, South Africa, New Zealand and countries in mainland Europe. Eligible patients who had a partial response or stable disease following standard first-line therapy with platinum/pemetrexed will be stratified to merlin low or high and then randomized to receive either placebo or 400 mg of defactinib. For more information visitwww.COMMANDmeso.com

Rays Blog http://mesoandme.wordpress.com/2014/07/11/friday-97/

http://onestopmesothelioma.co.uk/

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