Living With Mesothelioma- My Diary- What a night last night was ?? All ready for Mesothelioma Action Day Tomorrow


When people talk about heat waves and how bad the heat can make you in the past I have never really seen what they meant.

Being a dark haired brown eyed dark skin it hasn’t really meant anything to me. Summers have been hot in my life and I have loved it.

Well yesterday really knock me back. as the temperature rose I wilted. A wet rag in my chair with no energy what’s so ever.

The dog joined me and he panted so much I thought we were both going to heaven together.

I had been told by my nurse on Tuesday that a cancer patient must drink water as we are prone to DVT in hot weather so I kept drinking and drinking but that meant I was in and out of the Loo all day.

The temperature got up to 98.4F in the Lounge and 94F in the bedroom.

The fans were going as well. It was funny seeing the dogs fur all blowing up i the breeze.

DSCF3231

When we went to bed we just didn’t want to be there and I tossed and turned but I must have dropped off.

When we woke up I was really cool and it was great to get up and feel well again –Human.

Thank goodness for that. The day was so cool outside that the dog and myself went out early, it was 6am.

The world was quiet except for the cars speeding up the lane taking the early birds up to the motorway.

The world was very right again.

Thank Goodness the Operation Stack was able to thin out today as the Ferries are running a 2 hour service. that’s not a lot but it will clear it slowly.

Then a cleaning up operation has to happen before they can open the Motorway from Maidstone. it doesn’t bare thinking about. No loo’s for the poor men so we all know where they have had to go it must be a health hazard in this heat.

We had to go and buy the rail tickets for London for tomorrow to after lunch we trotted off to the station and I walked Louis again while ray bought them.

Im looking forward to speaking at :-

My Speech carries a message to the Asbestos Industry. We might be the patient but people forget the reason we are suffering is because of Asbestos therefore we are the experts, knowing what the dangers of the substance are. We have all had to study and find out where we were contaminated, therefore we are the best ones to talk about the subject. I want to show the people, who are responsible for dealing with it in public surroundings why they are doing the great job. To stop people suffering the way the Mesowarriors have.

Yesterday the world was on fire with so much research and drugs being talked about. Immunotherapy is really doing well and will soon be through as a drug but there are other trials with good drugs and great shrinkage going on,

We fund a lot of research into the deadly asbestos-related cancer, mesothelioma. With Action Mesothelioma Day coming up, we thought we’d share with you some of that work. Sarah is one of our researchers, read about her work to find better treatments for mesothelioma

Sarah shares her exciting research into treatments for mesothelioma, a devastating lung disease.

Sarah MartinMesothelioma, a deadly cancer caused by breathing in asbestos dust, devastates lives. Right now we have no cure for it, and only 1 out of every 10 people who are diagnosed will survive longer than three years.

But research has identified its Achilles’ heel. And now we want to find out how we can exploit it.

A critical need

Chemotherapy is often the go-to treatment for mesothelioma – but more than half of people gain only 2-3 more months of life, or fail to respond to it completely. It’s clear to me that there’s a critical need for a more focused approach to treatment.

To find more effective ways of helping people with mesothelioma, we need to learn what drives its growth.

I lead a team of 7 researchers, from PhD students to clinical research fellows and postdoctoral researchers, and our lab is focused on finding new ways of treating cancer based on their genetic makeup.

We first became interested in mesothelioma when working with Dr Peter Szlosarek, who discovered that half of mesothelioma tumours have lost the function of a certain gene called ASS1.

This gene produces an amino acid called ‘arginine’, which is one of the building blocks that cells – and so mesothelioma – need to grow.

Those mesothelioma tumours which have lost the ability to produce arginine themselves are forced to get it from the blood instead. So by blocking them from getting the arginine, we can kill the cancer cells. A recent clinical trial attempted this, and we saw encouraging activity.

Our research

In our research, we use a library of drugs that have been used to treat other conditions to see if they have any positive effect in treating mesothelioma. We’re looking for a drug that might treat those mesothelioma tumours which don’t produce arginine.

These drugs will potentially kill the tumour cells without harming the healthy cells, reducing the difficult side-effects that often happen with chemotherapy. They could be used alone, or in combination with other drugs that starve mesothelioma of arginine.

This approach is called ‘synthetic lethality’ and has been successful for treating some breast cancers and ovarian cancers which are deficient in a different gene.

Excitingly, we have already found some approaches that we’re investigating further. They suggest that we might be able to stop the cancer becoming resistant to the drugs used to treat it, which is often a big obstacle in cancer treatment.

Ultimately, drugs that look promising which we think could effectively be used to help people with mesothelioma will be taken forward into the clinic.

The inability to produce arginine is common to several difficult to treat cancers, so our work could potentially shed new light on those too.

Making a difference

It’s always challenging when experiments we hoped would be successful don’t work, or when results happen very slowly, and especially when people’s lives are so dependent on it.

But it’s the days where an important experiment gives us good results that make those tough times worth it. When that happens, you know those results could mean a new way of treating people and change everything for them and their families.

We’re working with the British Lung Foundation on this project as they have a specific interest in mesothelioma, and unfortunately it’s difficult for research into this condition to be supported by the major research funding agencies. But as a charity, they depend on your generous donations to keep investing into our work.

Action Mesothelioma Day is an opportunity to talk about this deadly lung condition so that we can make more people aware of its devastating impact, but also the great opportunities research can provide.

Contact St Barts for this Trial —

http://blog.blf.org.uk/2015/06/mesothelioma-research-action-on-arginine/

Verastem: Novel Drugs Targeting Cancer Stem Cells

Verastem, Inc. (NASDAQ: VSTM) is a clinical-stage biopharmaceutical company focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells. Cancer stem cells are an underlying cause of tumor recurrence and metastasis. Verastem is developing small molecule inhibitors of signaling pathways that are critical to cancer stem cell survival and proliferation: FAK, PI3K/mTOR and Wnt.

Verastem has contacted and they are doing well with the Command Trial which is in many Cancer Hospitals now.

Please get on these trials they need our backing as the Drug Companies are really putting everything in to find us a drug to beat Mesothelioma.

http://phx.corporate-ir.net/phoenix.zhtml?c=250749&p=irol-news&nyo=0

Over the next 30 years, it’s expected that 60,000 people will die as a result of mesothelioma. Yet far less funding is invested into researching this cancer than into diseases that kill similar numbers of people, such as skin cancer.

http://www.nursingtimes.net/student-nursing-times/virtual-placement/those-affected-by-mesothelioma-deserve-far-better-than-what-theyve-had-over-the-past-20-years/5087076.article

Mesothelioma care has come a long way in the past 20 years, explains specialist nurse Leah Taylor

Leah Taylor and Chris Knighton

My first experience of mesothelioma was as a student nurse 20 years ago. I cared for a woman who had been exposed to asbestos dust while washing her husband’s overalls. I remember being shocked that so little was known about this devastating disease and that there was neither treatment nor cure. All I could do was manage her symptoms.

Mesothelioma is a type of cancer of the lung lining mainly caused by exposure to asbestos. Most people will die within months of their diagnosis and fewer than one in ten will survive three years.

Over the next 30 years, it’s expected that 60,000 people will die as a result of mesothelioma. Yet far less funding is invested into researching this cancer than into diseases that kill similar numbers of people, such as skin cancer.

Change is coming about,slowly but surely. But there is still so much to be done to support people affected by this terrible condition.

I can’t imagine doing anything else other than being a nurse and caring for people. Looking after people with cancer and those at the end of life have always been the parts of nursing I’ve found most rewarding.“Looking after people with cancer and those at the end of life have always been the parts of nursing I’ve found most rewarding”

When I heard that the Mick Knighton Mesothelioma Research Fund (MKMRF) – part of the British Lung Foundation – had decided to fund the first ever mesothelioma clinical nurse specialist in the North East, I knew I couldn’t pass up the opportunity.

The north east is one of the areas worst affected by the disease in the UK.  As a mesothelioma nurse specialist I’m able to provide much needed support, care and access to information about new research and treatments for those affected by mesothelioma.

I treat patients in Northumberland and North Tyneside and work with other regional teams to improve access to support groups, treatments and information. As nurse lead for mesothelioma, I am also responsible for ensuring mesothelioma issues are raised regionally.“This is an important time for mesothelioma care in the UK”

There’s so much that I enjoy about being a mesothelioma nurse specialist, but I particularly love the interaction with patients and the knowledge that I can help – even in a small way – at a time that is so difficult for them. I love that no two days are ever the same and I feel I’m always learning something new.

This is an important time for mesothelioma care in the UK. Nurse specialists have the potential to significantly transform care for those affected by mesothelioma. There are currently ten mesothelioma clinical nurse specialists here and I’m very excited to see how this network of expertise develops both in my region and in other parts of the country.“I feel proud to be able to say I’m part of this new chapter in mesothelioma care”

Those affected by mesothelioma deserve far better than what they’ve had over the past 20 years. I feel very privileged to be working with the MKMRF and the BLF and I feel proud to be able to say I’m part of this new chapter in mesothelioma care.

Leah is based at North Tyneside General Hospital, part of Northumbria Healthcare NHS Foundation Trust. Leah is doing her part but there is only so much she can do without more investment in research to improve treatments, prognosis and perhaps one day, develop a cure. You can help by joining the BLF’s campaign to create a sustainable research fund. You can get involved and support our campaign for mesothelioma research.

So Good Luck all the people around the Country I hope your Mesothelioma Action Day all go well. and lets really report what we do lets really raise the awareness.

Rays Blog —————————-

Last night was intolerable neither of us could sleep and louis was in a state. But today has been a lot better ,still warm. I had to go to the station to get tickets. I was amazed. the journey to london we usualy make is after 9 am and its £52 for 2. But because we need to go before the 9 am watershed it was £118. [ 68 more words. ]

https://mesoandme.wordpress.com/2015/07/02/thursday-128

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